Dexamethasone Sodium Phosphate is a water-soluble, synthetic glucocorticoid. It is the disodium salt of dexamethasone-21-phosphate. It appears as a white to almost white crystalline powder, freely soluble in water and slightly soluble in alcohol. It is odorless and has a bitter taste.
Indications (Therapeutic Use)
This API is used in the manufacture of injectable solutions, ophthalmic preparations (eye drops/ointment), and oral solutions for the treatment of:
✓Respiratory diseases: COVID-19 (severe/critical cases, based on clinical guidelines), acute respiratory distress syndrome (ARDS).
✓Neurological disorders: Cerebral edema (associated with brain tumors or neurosurgery).
✓Oncology: Part of combination chemotherapy regimens (e.g., for multiple myeloma, lymphoma) to reduce inflammation and treat chemotherapy-induced nausea/vomiting.
Storage & Packaging
●Storage condition: Store protected from light, in a well-closed container, at controlled room temperature (15°C–25°C) or as recommended by the manufacturer. Avoid excessive heat and humidity.
●Packaging: Double LDPE liner inside fiber drums or HDPE drums (typically 1 kg, 5 kg, 10 kg, 25 kg net weight). Smaller packaging available for R&D.
Frequently Asked Questions (FAQ)
1. What is the physical appearance of Dexamethasone Sodium Phosphate API?It is a white to almost white crystalline powder that is odorless and has a bitter taste.
2. Is Dexamethasone Sodium Phosphate soluble in water?Yes, it is a water-soluble synthetic glucocorticoid, appearing as the disodium salt of dexamethasone-21-phosphate.
3. What types of final pharmaceutical forms can be made from this API?It is commonly used to manufacture injectable solutions, ophthalmic eye drops or ointments, and oral liquid solutions.
4. How should the API be stored to ensure stability?It should be stored in a well-closed container, protected from light, and kept at controlled room temperatures between 15°C and 25°C.
5. In what industry-standard packaging is it supplied?Standard packaging includes double LDPE liners inside fiber or HDPE drums, typically in sizes of 1kg, 5kg, 10kg, and 25kg.
6. Can it be used for treating respiratory conditions like COVID-19?Yes, according to clinical guidelines, it is indicated for severe or critical cases of COVID-19 and acute respiratory distress syndrome (ARDS).
