High-Quality Aceglutamide for injection used for traumatic coma Supplier, Suppliers

Aceglutamide for injection

Specification: 6vials/Box ,600boxes/CTN

Trademark: Serumpharm

Support OEM/ODM: Yes

Mini. Order: 12000 Boxes

Delivery Time: 50~60 Days

Trade Term: FOB,CIF

Payment Term: T/T,L/C

Standard Available: CP,BP

Documents: GMP,COPP,CTD

Product Description

1
General Information

[Ingredients]: The main component of this product is acetylglutamine. The auxiliary material is mannitol.

[Chemical Name]: N2-acetyl-L-glutamine

Molecular Formula: C7H12N2O4
Molecular Weight: 188.18
Character: White block solid or powder.
2
Indications & Usage

[Indication]: Used for traumatic coma, neurosurgery caused by coma, liver coma and hemiplegia, high paraplegia, polio sequelae, nerve headache, and lumbpain, etc.

[Specification]: (1) 0.3g | (2) 0.6g

[Usage and Dosage]:

  • Intramuscular injection: 300-600mg per day; dose reduction in children or as advised.
  • Injection: 300-600mg each time, diluted slowly in 5% or 10% 250ml glucose. Dose reduction in children or as prescribed.
3
Adverse Reactions & Precautions

[Untoward Effect]: Potential reactions include:

Systemic: shivering, chills, fever, fatigue.
Skin: flushing, rash, itching, erythema, sweating.
Digestive: nausea, vomiting, abdominal pain, diarrhea.
Neurological: dizziness, headache, tremor, anxiety, insomnia.

[Points for Attention]:

  • Quiet drops may cause blood pressure to drop.
  • Prohibition of use when their physical traits change.
4
Pharmacology & Pharmacokinetics

Pharmacological Toxicology: Acetylglutamine decomposes into glutamate and γ-aminobutyric acid (GABA) after passing through the blood-cerebrospinal fluid barrier. It improves nerve cell metabolism, maintains nerve stress ability, reduces blood ammonia, and improves brain function.

Pharmacokinetics: Widely distributed in the body (highest in brain, liver, and kidney). It passes through the blood-cerebrospinal fluid barrier. Ammonia is secreted and excreted through renal tubules, while acetylglutamate is absorbed for metabolism.

5
Storage & Packaging
Store Hidden Shading, closed preservation.
Packaging Vial box, 6 vials / box
Expiry Date 24 months
Implementation Standard YBH12832005-2014Z
Approval No. H20050987 / H20050988
Frequently Asked Questions (FAQ)
What are the primary uses of Acetylglutamine?
It is primarily used for treating traumatic coma, coma resulting from neurosurgery, hepatic coma, hemiplegia, and polio sequelae. It is also effective for nerve-related headaches and lumbpain.
How is this medication administered?
It can be administered via intramuscular injection (300-600mg daily) or via slow intravenous injection diluted in 5% or 10% glucose solution.
Are there any special precautions regarding blood pressure?
Yes, quiet or rapid drops of the medication may cause a decrease in blood pressure. Vital signs should be monitored during administration.
Can children and elderly patients use this product?
For children, the dose should be reduced as prescribed by a doctor. For elderly patients, treatment should follow the standard dosage guidelines as no specific study data is currently available.
How does Acetylglutamine work in the brain?
It crosses the blood-brain barrier and decomposes into glutamate and GABA, which help maintain nerve cell metabolism, improve brain function, and reduce blood ammonia levels.
What is the shelf life and storage requirement?
The product has a shelf life of 24 months. It must be stored in a shaded, closed container to maintain its stability.

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