Treatment of infections caused by penicillin-sensitive Gram-positive bacteria as well as H. Influenzae, E. Coli, P. Mirabilis, Salmonella and some Shigellosis species. It is indicated for the treatment of bronchitis, otitis media, bacterial pharyngitis, bacterial pneumonia, sinusitis, and urinary tract infections.

Contraindicated in individuals with a history of an allergic reaction to the penicillins. Amoxicillin is also contraindicated in patients with a history of amoxicillin-associated hepatic dysfunction of jaundice.

Sensitivity reactions are more likely to occur in individuals who have previously demonstrated hypersensitivity to penicillins and in those with a history of allergy, asthma, hay fever, or urticaria. The hypersensitivity reactions are Erythematous maculopapular rashes, urticaria, fever, and joint pains. Anaphylactic shock may occur.

• Gastrointestinal: Diarrhoea, nausea, vomiting, heartburn, and pseudomembranous colitis.
• Liver: A moderate rise in serum glutamic oxalacetic transaminase has been noted, but the significance of this finding is unknown.
• Haemic and Lymphatic Systems: Anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and granulocytopenia have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy.
• Central Nervous System: Reversible hyperactivity, agitation, anxiety, confusion, behavioural changes, and/or dizziness.

Amoxicillin Capsule is synergistically active with aminoglycosides with balanced dosages and also shows a good synergistic effect with TMP. If employed together with benemid, tubular secretion will be decreased, the serum concentration of amoxicillin will go up, and the half-life will extend. Chloromycetin, macrolides, sulfa, and tetracycline will interfere with the product’s antibacterial activity. Amoxicillin must not be employed together with vitamin C and sodium bicarbonate.

Hepatic: A moderate rise in AST has been noted, but the significance of this finding is unknown.

Haematologic: Reactions such as anaemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leucopenia, and agranulocytosis have been reported during therapy. These reactions are usually reversible upon discontinuation of therapy.

Animal reproduction tests show that 10 times the human dose of amoxicillin does not damage the fertility and fetus of rats and mice. However, adequate studies in humans are still lacking. As animal reproduction tests cannot fully predict human response, pregnant women should not use this medication unless absolutely necessary. Since breast milk can secrete small amounts of amoxicillin, it may cause allergies in nursing infants.

A prospective study involving 51 pediatric patients shows that when the amoxicillin dosage does not exceed 250mg/kg, it does not cause significant clinical symptoms. It has been reported that a minority of patients experience renal insufficiency and oliguria after an overdose, but this renal dysfunction is fully reversible upon discontinuation of the drug.

Store below 25°C. Protect from moisture. Keep out of reach of children.